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Interpretation 260
Tier 3
APC
Variants
Primary Sites
Prostate
Tumor Types
Adenocarcinoma
Interpretation

The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. APC promotes rapid degradation of beta-catenin and participates in Wnt signaling as a negative regulator. APC is also involved in other processes including cell migration, cell adhesion, transcriptional activation and apoptosis. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. APC mutations have been reported in 3-10% of prostate cancers. In some studies, a high-level of APC promoter methylation was shown to be an independent predictor of a poor prognosis in prostate cancers. However, further studies are needed to explore the clinical value of APC mutations in these tumors.

Citations
  1. Khemlina G, et al. Molecular landscape of prostate cancer: implications for current clinical trials. Cancer Treat Rev 2015;41(9):761-6
  2. Henrique R, et al. High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients. Clin Cancer Res 2007;13(20):6122-9
  3. Kypta RM, et al. Wnt/b-catenin signalling in prostate cancer. Nat Rev Urol 2012;9(8):418-28
Last updated: 2016-04-17 17:40:57 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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