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FGFR1
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Interpretation 255
Tier 1
FGFR1
Variants
FGFR1 copy number gain
Primary Sites
Breast
Tumor Types
Invasive Ductal Carcinoma
Interpretation

Amplification of FGFR1 has been reported in approximately 10% of breast cancer and may be associated with adverse outcome according to some reports. It has been reported to be associated with increased expression of FGFR1 and increased activity of downstream growth signaling pathways. Some reports suggest FGFR1 may have a role in regulating response to endocrine therapy. FGFR1 amplification may be a targetable alteration in some clinical settings (PubMed IDs: 20179196, 25400686).

Citations
  1. Turner N, et al. FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res 2010;70(5):2085-94
  2. Brady N, et al. The FGF/FGFR axis as a therapeutic target in breast cancer. Expert Rev Endocrinol Metab 2013;8(4):391-402
Last updated: 2016-04-09 18:01:57 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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