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STK11
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Interpretation 2318
Tier 2
STK11
Variants
STK11 codon(s) 60-1 deletion
Primary Sites
Peritoneum
Tumor Types
Unknown
Interpretation

The STK11 is a tumor suppressor gene located on chromosome 19p13.3. The encoded protein has serine--threonine kinase activity. Functionally, STK11 regulates cellular energy metabolism and cell polarity by activating AMP-activated protein kinase (AMPK) and other members of the AMPK family. Germline mutations in the STK11 gene are responsible for Peutz--Jeghers syndrome, an autosomal dominant disorder with variable clinical phenotype and increased risk of some cancers. Somatic inactivating mutations of STK11 gene are reported in several tumors. Clinical relevance of these alterations and impact on disease progression and patient survival needs to be fully elucidated.

Citations
  1. Sanchez-Cespedes M, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002;62(13):3659-62
  2. Sanchez-Cespedes M A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome. Oncogene 2007;26(57):7825-32
Last updated: 2019-01-22 18:51:26 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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