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BRINP3
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Interpretation 2277
Tier 3
BRINP3
Variants
BRINP3 any mutation
Primary Sites
Blood
Bone Marrow
Tumor Types
Acute Myeloid Leukemia
Acute Leukemia of Unspecified Cell Type
Anemia, Unspecified
Cytopenia
Leukocytosis
Leukopenia
Monocytosis
Other Acute Leukemia
Thrombocytopenia, Unspecified
Interpretation

BRINP3(FAM5C) has been reported to be mutated in <10% of some types of AML.

Citations
  1. Eisfeld AK, et al. Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole Abnormality. Cancer Res 2017;77(1):207-218
  2. Welch JS, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 2012;150(2):264-78
  3. Riva L, et al. Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups. Blood Cancer J 2014;4():e195
  4. Riva L, et al. Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups. Blood Cancer J 2013;3():e147
Last updated: 2018-11-12 20:40:58 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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