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NRAS
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Interpretation 2254
Tier 2
NRAS
Variants
NRAS G12A
NRAS G12V
NRAS G12D
NRAS G12C
NRAS G12S
NRAS G12R
NRAS G13D
NRAS G13C
NRAS G13S
NRAS G13R
NRAS G13A
NRAS G13V
NRAS Q61H
NRAS Q61L
NRAS Q61K
NRAS Q61R
Primary Sites
Kidney
Tumor Types
Urothelial Carcinoma
Interpretation

NRAS gene belongs to the family of RAS genes. It encodes a G protein that is important in the transmission of growth-promoting signals from the cell surface receptors to the nucleus through RAS-RAF- mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)-AKT cell signaling pathways. NRAS mutations are identified in multiple cancer types and tend in concentrate in codons 12, 13, and 61. NRAS mutations are rare in urothelial carcinomas of both the upper and lower urinary tract and are found in about 1% of cases. Currently, there are no direct anti-NRAS therapies available. The clinicopathologic significance of NRAS mutations in urothelial carcinoma remains to be further elucidated.

Citations
  1. Fernandez-Medarde A, et al. Ras in cancer and developmental diseases. Genes Cancer 2011;2(3):344-58
  2. Sfakianos JP, et al. Genomic Characterization of Upper Tract Urothelial Carcinoma. Eur Urol 2015;68(6):970-7
  3. https://tcga-data.nci.nih.gov/docs/publications/tcga/?
Last updated: 2018-05-24 20:15:40 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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