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BRAF

Interpretations

By Variant(s)

BRAF D594G

BRAF G469E

BRAF L597V

BRAF V600D

BRAF V600E

BRAF V600K

BRAF V600R

BRAF codon(s) 600 any

BRAF G469A

BRAF codon(s) 469 any

BRAF G464V

BRAF codon(s) 464 any

BRAF K601E

BRAF codon(s) 601 any

BRAF D594E

BRAF codon(s) 594 any

BRAF T599_V600insT

BRAF T599_V600insV

BRAF F595S

BRAF L597R

BRAF G466V

BRAF N581S

BRAF E586K

BRAF V600M

BRAF D594N

BRAF G469V

BRAF L597Q

BRAF L597S

BRAF V600G

BRAF G596C

BRAF copy number gain

BRAF copy number loss

BRAF any mutation

BRAF G469R

BRAF G466R

BRAF F468S

By Tumor

  • Acinar Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Acinic Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Acute Myeloid Leukemia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Adenocarcinoma
    • BRAF V600E, BRAF codon(s) 600 any, BRAF V600D, BRAF V600K, BRAF V600R, BRAF V600M, BRAF V600G
    • BRAF V600D, BRAF V600K, BRAF V600R, BRAF V600M, BRAF V600G
    • BRAF G469A, BRAF codon(s) 469 any
    • BRAF G464V, BRAF codon(s) 464 any
    • BRAF K601E, BRAF codon(s) 601 any
    • BRAF D594E, BRAF codon(s) 594 any
    • BRAF G466V
    • BRAF G469A
    • BRAF N581S
    • BRAF codon(s) 594 any
    • BRAF codon(s) 594 any
    • BRAF E586K
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
    • BRAF V600E
    • BRAF G466R
    • BRAF G469V
    • BRAF G466V
  • Adenoid Cystic Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Adenosarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Ameloblastic Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Anaplastic Large Cell Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Angioimmunoblastic T-Cell Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Angiomatoid Fibrous Histiocytoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Angiomatosis
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Angiomyolipoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Angiosarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Astrocytoma, Anaplastic
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Atypical Chronic Myeloid Leukemia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • B Lymphoblastic Leukemia/Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Basal Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Burkitt Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Carcinoid Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Carcinoma
    • BRAF G466V
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Carcinosarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Cholangiocarcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Chondrosarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Chordoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Choriocarcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Chromophobe Renal Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Chronic Lymphocytic Leukemia
    • BRAF V600D, BRAF V600E, BRAF V600K, BRAF V600R, BRAF codon(s) 600 any, BRAF V600M, BRAF V600G
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
    • BRAF K601E
  • Chronic Myeloid Leukemia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Chronic Myelomonocytic Leukemia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Chronic Neutrophilic Leukemia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Classical Hodgkin Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Clear Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Clear Cell Renal Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Craniopharyngioma
    • BRAF V600E
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Dermatofibrosarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Desmoplastic Small Round Cell Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Diffuse Large B Cell Lymphoma
    • BRAF V600D, BRAF V600E, BRAF V600K, BRAF V600R, BRAF codon(s) 600 any, BRAF V600M, BRAF V600G
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Ductal Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Ependymoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Essential Thrombocythemia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Ewing Sarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Fibromatosis
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Follicular Carcinoma
    • BRAF K601E
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Follicular Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Gastrointestinal Stromal Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Germ Cell Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Giant Cell Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Glioblastoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Glomus Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Granular Cell Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Hairy Cell Leukemia
    • BRAF V600D, BRAF V600E, BRAF V600K, BRAF V600R, BRAF codon(s) 600 any, BRAF V600M, BRAF V600G
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Hemangioendothelioma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Hepatocellular Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Histiocytic and Dendritic Cell Neoplasms
    • BRAF V600D, BRAF V600E, BRAF V600K, BRAF V600R, BRAF codon(s) 600 any, BRAF V600M, BRAF V600G
    • BRAF V600E, BRAF codon(s) 600 any
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Invasive Ductal Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Kaposi Sarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Langerhans Cell Histiocytosis
    • BRAF V600D, BRAF V600E, BRAF V600K, BRAF V600R, BRAF codon(s) 600 any, BRAF V600M, BRAF V600G
    • BRAF V600E, BRAF codon(s) 600 any
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
    • BRAF V600D
    • BRAF codon(s) 600 any, BRAF V600G
    • BRAF codon(s) 600 any, BRAF V600M
  • Leiomyoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Leiomyosarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Lipoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Liposarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Lobular Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Lymphoplasmacytic Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Malignant Mullerian Mixed Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Mantle Cell Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Marginal Zone B Cell Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Mast Cell Neoplasm
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • MDS with Ring Sideroblasts
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Medullary Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Medulloblastoma
    • BRAF F595S
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Melanoma
    • BRAF V600E, BRAF codon(s) 600 any, BRAF V600D, BRAF V600K, BRAF V600R, BRAF V600M, BRAF V600G
    • BRAF L597V, BRAF L597R
    • BRAF G466V
    • BRAF N581S
    • BRAF codon(s) 594 any
    • BRAF G464V, BRAF codon(s) 464 any
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
    • BRAF G469R
    • BRAF L597Q
    • BRAF K601E, BRAF codon(s) 601 any
    • BRAF codon(s) 469 any, BRAF G469V
    • BRAF D594N
    • BRAF V600G
    • BRAF V600D, BRAF codon(s) 600 any
    • BRAF G469A
    • BRAF V600K
    • BRAF G596C
    • BRAF codon(s) 600 any, BRAF V600M
    • BRAF L597S
  • Meningioma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Merkel Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Mesothelioma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Mucinous Tumors of Appendix
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Mucinous Tumors of Ovary
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Mucoepidermoid Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Myelodysplastic Syndrome
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Myeloproliferative Neoplasm
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Myxofibrosarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Nasopharyngeal Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Neuroblastoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Neuroendocrine Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Neuroendocrine Neoplasm
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • NK Cell Lymphoproliferative Disorder
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • NLPHL
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Non-Small Cell Lung Carcinoma
    • BRAF G466V
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
    • BRAF V600G
    • BRAF V600D
    • BRAF codon(s) 600 any, BRAF V600M
  • Oligodendroglioma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Osteosarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Papillary Carcinoma
    • BRAF V600E, BRAF codon(s) 600 any
    • BRAF T599_V600insV
    • BRAF K601E
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
    • BRAF F468S
  • Papillary Renal Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Peripheral T Cell Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Pheochromocytoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Plasma Cell Disorder
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Polycythemia Vera
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Post-Transplant Lymphoproliferative Disorder
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Primary Myelofibrosis
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Primitive Neuroectodermal Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Renal Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Reninoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Retinoblastoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Rhabdomyosarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Sarcoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Schwannoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Serous Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Sex Cord Stromal Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Small Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Solid Pseudopapillary Tumor of Pancreas
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Spindle Cell Neoplasm
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Squamous Cell Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
    • BRAF G469A
  • T Cell Lymphoproliferative Disorder
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • T Lymphoblastic Leukemia/Lymphoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • T-Cell LGL Leukemia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Thymic Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Thymoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Urothelial Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
    • BRAF V600E
    • BRAF K601E
  • Tumors of Peripheral Nerves
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Unknown
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Wilms Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Ependymoma, Anaplastic
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Astrocytoma, Pilocytic
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Ganglioglioma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Neuroepithelial Neoplasm, NOS
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Pleomorphic Carcinoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Solitary Fibrous Tumor
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Neuroepithelial neoplasm, high grade
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Leukocytosis
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Thrombocytosis
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Monocytosis
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Cytopenia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Other Acute Leukemia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Astrocytoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Acute Leukemia of Unspecified Cell Type
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Anemia, Unspecified
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Astrocytoma, Diffusely Infiltrating
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Diffuse Midline Glioma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Infiltrating Glioma, NOS
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Intraductal Papillary Mucinous Neoplasm (IPMN)
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Leukopenia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Lymphadenopathy
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Lymphocytosis, Symptomatic
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Monoclonal Gammopathy
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Mucinous or Serous Cystic Neoplasms of Pancreas
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Mycosis Fungoides, Unspecified Site
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Oligodendroglioma, Anaplastic
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Pleomorphic Xanthoastrocytoma
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Rash and Other Nonspecific Skin Eruption
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Thrombocytopenia, Unspecified
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Eosinophilia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Myelodysplastic/Myeloproliferative Neoplasm
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Myeloid Neoplasm
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Polycythemia
    • BRAF copy number gain, BRAF copy number loss
    • BRAF any mutation
  • Information
  • View History
  • Suggested Revisions
Interpretation 2172
Variant(s)BRAF V600D
Tumor(s)Langerhans Cell Histiocytosis
Tissue(s)Unknown
Tier1
Interpretation

Vemurafenib

Citations

Flaherty KT, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363(9):809-19

Hyman DM, et al. Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations. N Engl J Med 2015;373(8):726-36

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