PMKB
PMKB
Genes
Variants
Interpretations
Tumor Types
Primary Sites
Activity
Login
KIT
Information
View History
Pending Review
Interpretation 2169
Tier 1
KIT
Variants
KIT D816F
KIT D816V
KIT D816Y
Primary Sites
Unknown
Tumor Types
Gastrointestinal Stromal Tumor
Interpretation
Dasatinib Nilotinib
Citations
von Mehren M Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors. Clin Colorectal Cancer 2006;6 Suppl 1():S30-4
Reichardt P, et al. Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib. Ann Oncol 2012;23(7):1680-7
Sawaki A, et al. Phase 2 study of nilotinib as third-line therapy for patients with gastrointestinal stromal tumor. Cancer 2011;117(20):4633-41
Montemurro M, et al. Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib. Eur J Cancer 2009;45(13):2293-7
Last updated: 2018-04-06 15:15:55 UTC
PMKB Bot
Genes
Variants
Interpretations
Tumor Types
Primary Sites
Activity