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NTRK1
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Interpretation 2123
Tier 1
NTRK1
Variants
NTRK1 any mutation
Primary Sites
Brain
Tumor Types
Infiltrating Glioma, NOS
Astrocytoma, NOS
Astrocytoma, Diffusely Infiltrating
Diffuse Midline Glioma
Neuroepithelial Neoplasm, NOS
Interpretation

NTRK1, NTRK2, and NTRK3 alterations, including gene fusion events, have been described in a subset of infiltrating gliomas including pediatric high grade infiltrating astrocytomas within the cerebral hemispheres as well as diffuse midline gliomas.

Citations
  1. Wu G, et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet 2014;46(5):444-450
Last updated: 2018-02-27 06:15:44 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017

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