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NRAS
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Interpretation 170
Tier 2
NRAS
Variants
NRAS G12A
NRAS G12V
NRAS G12D
NRAS G12C
NRAS G12S
NRAS G12R
NRAS G13D
NRAS G13C
NRAS G13S
NRAS G13R
NRAS G13A
NRAS G13V
NRAS Q61H
NRAS Q61L
NRAS Q61K
NRAS Q61R
NRAS codon(s) 12, 13, 61, 146 any
Primary Sites
Bladder
Tumor Types
Urothelial Carcinoma
Interpretation

NRAS is a member of the RAS family of oncogenes and activating mutations of NRAS have been reported in a wide variety of tumors including occasional cases of bladder cancer. This finding may influence targeted therapy options.

Citations
  1. Kompier LC, Lurkin I, van der Aa MN, van Rhijn BW, van der Kwast TH, Zwarthoff EC. FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy. PLoS One. 2010 Nov 3;5(11):e13821. doi: 10.1371/journal.pone.0013821. PubMed PMID: 21072204; PubMed Central PMCID: PMC2972209.
  2. Calderaro J, Rebouissou S, de Koning L, Masmoudi A, Hérault A, Dubois T, Maille P, Soyeux P, Sibony M, de la Taille A, Vordos D, Lebret T, Radvanyi F, Allory Y. PI3K/AKT pathway activation in bladder carcinogenesis. Int J Cancer. 2014 Apr 15;134(8):1776-84. doi: 10.1002/ijc.28518. Epub 2013 Oct 24. PubMed PMID: 24122582.
Last updated: 2017-01-20 03:27:37 UTC
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Disclaimer: You assume full responsibility for all risks associated with using this PMKB website. The Englander Institute for Precision Medicine at Weill Cornell Medicine makes no guarantee of the comprehensiveness, reliability or accuracy of the information on this website and assumes no responsibility for errors in the information associated with this web site. Healthcare providers and patients must integrate all clinical and laboratory findings as well as information from a variety of sources before deciding on appropriate clinical care options.


When using PMKB, please cite: Huang et al., JAMIA 2017


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