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NRAS
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Interpretation 167
Tier 1
NRAS
Variants
NRAS G12A
NRAS G12V
NRAS G12D
NRAS G12C
NRAS G12S
NRAS G12R
NRAS G13D
NRAS G13C
NRAS G13S
NRAS G13R
NRAS G13A
NRAS G13V
NRAS Q61H
NRAS Q61L
NRAS Q61K
NRAS Q61R
NRAS codon(s) 12, 13, 61, 146 any
Primary Sites
Thyroid
Tumor Types
Interpretation

RAS mutations have also been identified in benign Follicular Adenomas(FA); however, it is unclear whether RAS positive FA have a higher chance of progression to cancer. The prevalence of this mutation in benign thyroid nodules is between 20 and 40%. The low overall prevalence of RAS mutations in thyroid cancers and the relatively high mutation rate in benign nodules makes ras mutation analysis unsuitable as a standalone test to predict malignancy in indeterminate thyroid nodules.

Citations
  1. Keutgen et al...Molecular diagnosis for indeterminate thyroid nodules on fine needle aspiration: advances and limitations. Expert Rev. Mol. Diagn. 13(6), 613–623 (2013)
  2. Zhu Z et al.... Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity. J. Clin. Endocrinol. Metab. 91(9), 3603–3610 (2006).
Last updated: 2015-12-09 20:21:38 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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