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Interpretation 159
Tier 3
MET
Variants
MET E168D
Primary Sites
Lung
Tumor Types
Adenocarcinoma
Interpretation

The MET p. E168D mutation has been reported in various tumors including lung cancer according to the COSMIC database. Some studies indicate that this mutation may be associated with higher affinity for ligand, HGF. In vitro studies in cell lines with cells expressing MET p.E168D may show increased sensitivity to MET inhibitor. According to ClinVar, this particular variant is a likely benign germline variant (https://preview.ncbi.nlm.nih.gov/clinvar/variation/41627/). The clinical significance of this variant remains to be fully elucidated.

Citations
  1. Krishnaswamy et al Ethnic Differences and Functional Analysis of MET Mutations in Lung Cancer.Clin Cancer Res 2009;15(18) September 15, 2009
  2. ClinVar (https://preview.ncbi.nlm.nih.gov/clinvar/variation/41627/)
Last updated: 2019-02-22 18:05:13 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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