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IKZF3
Variants
VariantGeneTypeCOSMIC IDDNA Change (Coding Nucleotide)Exon

Interpretations

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IKZF3
Variants
Primary Sites
Blood
Bone Marrow
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Chronic Myeloid Leukemia
Interpretation

IKZF3 is a member of the IKAROS family of transcription factors which are important in lymphoid development. Missense and frameshift mutations of IKZF3 have been reported in approximately 10% of chronic phase and matched blast phase of CML , approximately 10% of blastic plasmacytoid dendritic cell neoplasms and rare cases of acute lymphoblastic leukemia.

Last updated: 2016-06-05 02:00:23 UTC
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When using PMKB, please cite: Huang et al., JAMIA 2017


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