Edit ID | Edit Comment | Time | |
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403278 | new interpretation by wei song | 04/05/2019 11:39 AM |
Mutations of the ESR1 gene have been increasingly recognized as an important mechanism of endocrine therapy resistance, with a prevalence that ranges from 11 to 39%. The majority of these mutations are located within the ligand-binding domain, especially codon 537 and 538, and result in an estrogen-independent constitutive activation of the ER and, therefore, resistance to estrogen deprivation therapy such as aromatase inhibition.