|Amino Acid Change||G776delinsVC|
|DNA Change (Coding Nucleotide)||p.M774_A775insAYVM|
|Transcript ID (GRCh37/hg19)||ENST00000269571|
|Genomic Coordinates (GRCh37/hg19)||17:37866607-37866608|
|2||The ERBB2 p.G776delinsVC variant is one of the in-frame insertions in exon 20 of ERBB2 that have been described in lung adenocarcinoma. Overall, in-frame ERRB2 insertions in exon 20 have been reported in approximately 6% of cases of lung adenocarcinoma which are negative for EGFR, KRAS, ALK alterations and these variants are more frequent in patients who were never-smokers. In vitro studies have shown that this specific variant is associated with constitutive kinase activation and is associated with sensitivity to some ERBB2 inhibitors and therefore, it may represent a targetable mutation in some clinical settings. Please refer to clinicaltrials.gov for additional information. Recommend correlation with other clinical and laboratory findings.|
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