KRAS codon(s) 12, 13, 61, 117, 146 any
Pancreatic ductal adenocarcinoma (PDAC) is initiated by oncogenic mutant KRAS, which has been shown to drive pancreatic neoplasia. More than 90% of pancreatic ductal adenocarcinoma samples have a KRAS mutation which may have prognostic, and (with ongoing trials assessing the efficacy of novel KRAS inhibitors) possibly therapeutic implications. However, targeting KRAS directly has been difficult in these tumors.
Eser et al.. Oncogenic KRAS signalling in pancreatic cancer. British Journal of Cancer (2014) 111, 817–822
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