|Amino Acid Change||L1195V|
|Transcript ID (GRCh37/hg19)||ENST00000318493|
Papillary Renal Cell Carcinoma
|2||Activating somatic mutations in the tyrosine kinase domain of MET are found in about 10–15% of sporadic papillary renal cell carcinoma (pRCC). MET mutations are predominantly associated with Type 1 pRCC tumors. The responses to foretanib an oral inhibitor of MET and other tyrosine kinases including VEGFR2, have been described in patients with papillary renal cell cancer.|
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