|Amino Acid Change||Q1429*|
|Transcript ID (GRCh37/hg19)||ENST00000457016|
APC codon(s) 1464 frameshift
APC codon(s) 1556 frameshift
APC codon(s) 1465 frameshift
APC codon(s) 1307 frameshift
|2||Somatic APC mutations are common events in colorectal adenocarcinomas, reported in up to 76% of the cases. Loss of normal APC function is known to be an early event in both familial and sporadic colon cancer pathogenesis, occurring at the pre-adenoma stage. APC mutations do not significantly affect the prognosis of colorectal cancer patients. While there are a number of small molecule inhibitors in development that target the Wnt pathway, there is currently no matched targeted therapy available for colorectal cancer patients harboring an APC mutation.|
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